Cannabis inhibits Spasticity
The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity.
The aim of this observational study was to assess the efficacy of a tetrahydrocannabinol-cannabidiol (THC : CBD) oromucosal spray on spasticity using the stretch reflex in patients with multiple sclerosis (MS). Numeric rating scale (NRS) for spasticity, modified Ashworth scale (MAS), and the stretch reflex were assessed before and during treatment in 57 MS patients with spasticity eligible for THC : CBD treatment. A significant reduction in stretch reflex amplitude as well as significant reductions of NRS and MAS scores were observed. There was a low concordance between the three measures (stretch reflex, NRS, and MAS), likely related to the different aspects of muscle hypertonia assessed. Stretch reflex responders were taking a significantly higher number of puffs, whereas no differences were found in the responders by the other scales, suggesting that a higher dosage would add benefit if tolerated. The present study confirms the efficacy of cannabinoids in reducing spasticity in patients with MS, suggesting a higher sensitivity and specificity of the stretch reflex compared with other measures. As an objective and quantitative measure of spasticity, the stretch reflex is particularly useful to assess the effects of cannabinoids on spinal excitability and may play a role in future pharmacological studies
It is amazing that in the clinical trials of oral cannabis and of sativex spray they could not find an effect on the Ashworth scale involving trials of hundreds of people but now in the post licencing age when we realise that some people respond and others do not that you can get positive effects with 30-60 people. In this study of savitex spray there were positive effects but worryingly there was poor correlation between physician assess Ashworth scale (what do your muscle look like (normal, stiff, very stiff etc), patient assessed responses (how do you feel out of a scale 1-10) or a stretch response.
But this study further supports our prior animal work that cannabinoids can control spasticity. However our prior work also shows the achilles heel of the approach is the side effect issue and the capacity to cause sedation and psychoactive effects and there is a small window between therapy and a high which some people do not want....some do.
CLICK HERE FOR DETAILS: https://clinicaltrials.gov/ct2/show/NCT02542787